Annonces professionnelles

PhD Research Fellowship in Biochemistry

Deadline: Thursday, September 17, 2020

Applications are invited for a 3-4 year position in a Research Fellowship as a PhD Candidate in Biochemistry to be based at the Institute of Basic Medical Sciences, University of Oslo.

The fellowship period is 3 years and devoted to carrying out part of the following project “Fibroblast Growth Factor 19, Pregnane X Receptor and the musculoskeletal system”. There exists a possibility to extend this period to 4 years with a compulsory workload of 25% that consists of teaching and supervision duties and research assistance.

Qualification requirements:

  • Applicants must hold a Master’s degree in a relevant field such as biochemistry, biology, molecular biology. A Master’s degree (120 ECTS) or an equivalent qualification, minimum grade B (ECTS grading scale) or equivalent. The Master’s degree must include a thesis of at least 30 ECTS
  • Experience with cells (skeletal muscle and bone cells) and/or mouse experiments is required
  • Authorization to work with animal research is necessary (LAS301)
  • Excellent fluent oral and written communication skills in English
  • Contribution to peer-reviewed article publication will be considered as highly positive

Fore more details, click here.


Postdoctoral position in Neurobiology
Lyon, France

A postdoctoral position is available in the laboratory of Julien Courchet at the NeuroMyoGene Institute within the University of Lyon, France.

Applicants should have a PhD degree or equivalent with a strong background and practical experience in neurobiology, confocal microscopy and/or real-time imaging. Previous experience working with rodent models is required. Training in techniques relevant to cell signaling, metabolic regulation and optogenetics would be an asset. We are looking for a highly motivated candidate with a strong attitude towards independent work and good interpersonal and communication skills.
Excellent written and spoken English skills are essential. Ability to speak French in not mandatory.
Candidates should hold a PhD in Neuroscience. Experience in cellular electrophysiology is mandatory and some background in cell imaging, in vivo electrophysiology or optogenetics would be a plus. The candidate should be highly motivated and organized, have good communication skills and should speak and write English fluently.

Interested candidates should contact Dr Julien Courchet (julien.courchet@univ-lyon1.fr) with their CV, a summary of their previous research (< 1 page), a brief statement of their research interests and career goals, as well as the contact information for at least 3 references.

Fore more details, click here.


Poste Technicien supérieur – Institut Pasteur
2 ans à partir d’octobre/novembre 2020

Nous recherchons un(e) technicien(ne)/Ingénieur(e) ayant une expertise dans plusieurs de ces domaines suivants : histologie, biologie cellulaire, culture cellulaire, expérimentation animale (souris), expertise de travail en P2+/P3 est un plus, compréhension de l’anglais.

Veuillez envoyer un seul PDF avec lettre de motivation (1 page maximum) + curriculum vitae et coordonnées de vos références au Dr. Barbara Gayraud-Morel à l’adresse mail : bgayraud@pasteur.fr.

Pour plus d’informations, cliquez ici.


A two year postdoctoral position is available immediately at the Institut de Génomique Fonctionnelle (IGF, Montpellier)

Microglia in the wiring of Inhibitory circuits during sensory cortex critical periods (ANR MicroSenso)

the MicroSenso project aims at studying the mechanisms by which microglial cells influence the wiring of inhibitory circuits during developmental critical periods of sensory cortices. The project will combine different functional approaches (ex vivo slice and in vivo electrophysiology, calcium imaging and optogenetics) to analyze different mouse models (microglia depletion, maternal immune activation, microglia and interneurons conditional KI and KO mice). The project funded by ANR will be performed in the team “Cerebrovascular and Glia Research” (Co-PIs E Audinat & N Marchi) of the IGF in Montpellier and in collaboration with the teams of S Garel (ENS, Paris) and N Rouach (Collège de France, Paris).

Candidates should hold a PhD in Neuroscience. Experience in cellular electrophysiology is mandatory and some background in cell imaging, in vivo electrophysiology or optogenetics would be a plus. The candidate should be highly motivated and organized, have good communication skills and should speak and write English fluently.

Send your CV and a motivation letter mentioning two references to etienne.audinat@igf.cnrs.fr.

Fore more details, click here.


Post-doc position in K. Jagla lab

Characterization of molecular determinants and cellular pathways controlling muscle fiber splitting

The goal of this project is to identify molecular determinants and characterize cellular pathways controlling muscle fiber splitting. Our preliminary data in Drosophila model (Bertin et al., bioRxiv, 2019) indicate that affected muscle identity information and/or locally induced excessive myoblast fusion could result in split muscle phenotype. Consistent with this observation, we identified Gelsolin as muscle identity realisator gene, which acts to limit fusion events and prevents muscles from splitting. Gelsolin belongs to the conserved family of actin severing proteins whose impact on muscle formation remains unknown. Within this project it is expected to: i) apply Drosophila model to functionally dissect the role of Gelsolin and Gelsolin-like proteins in regulation of myoblast fusion arrest and in preventing split phenotype; ii) analyse single nuclei RNAseq datasets from split fibers of mdx mutant mice (collaboration with C. Birchmeier, MDC Berlin) and determine associated gene expression signature(s); iii) analyse functionally the potential mdx-split hits in Drosophila model and on the “split fiber on the dish” system of differentiated iPSCs (collaboration with O. Pourquié, Harvard, Boston).

Send your application (motivation letter with indication of contacts for reference) to christophe.jagla@uca.fr before September 1st 2020. Position is available for 2 years from October 2020 with a possibility of extension.

Fore more details, click here.


Funded PhD project at IGBMC – Strasbourg – France

Project :
The PhD student will use next generation sequencing strategies, exome and genome sequencing of patients DNA, and RNAseq/transcriptome from patient muscles, and process these big datasets through bioinformatics pipelines to identify mutated genes in patients with myopathies. The functional impact of mutations will be confirmed by in vitro assays with recombinant proteins and transfected and differentiated muscle cells followed by confocal and video microscopies. The importance of these new myopathy genes for muscle function will be evaluated in vivo in an animal model (zebrafish or mice depending on the gene conservation) with CRISPR/Cas9 genome editing, RNA interference and adeno-associated virus. Animals will be phenotyped with simple motor tests, histology, electron microscopy and confocal imaging. This will also provide faithful laboratory models in which therapies may be later tested.
The success of this project will lead to a better diagnosis and patient care, and the identified genes will increase our understanding of the pathomechanisms and represent novel therapeutic targets.

Application:
Please send your CV, letters of recommendation and Master results to J Laporte (jocelyn@igbmc.fr) and J Bohm (johann@igbmc.fr)

Fore more details, click here.


Post-doctoral position at the Institute of Genetics and Molecular and Cellular Biology

(Illkirch, France) in the team of Daniel Metzger

The project aims at understanding the molecular mechanisms underpinning the tissue specificity and the crosstalk between steroid hormone receptors through integrative analyses. Our team has recently developed projects based on genomewide characterization of transcription factor cistromes and transcriptomes in various tissues of genetically modified mice, thereby providing the unique opportunity to decipher the in vivo mode of action of nuclear receptors. The fellow’s tasks will be to identify tissuespecific receptor partners and characterize the associated epigenetic marks using cuttingedge technics like Atac-seq, Hi-C and Rapid Immunoprecipitation Mass Spectrometry (RIME). Genome-wide data obtained in various tissues will be strengthened in in vitro models to delineate these complex molecular mechanisms.

Candidates should send a curriculum vitae with a publication list, a short summary of research achievements and mastered techniques, as well as contact information of at least two references to metzger@igbmc.fr.

For more details click here.


Chercheur CDD biologie du muscle (sarcopénie et pathologie inflammatoire)

Offre pour un (.e) jeune cherch.eur (.euse) titulaire d’un doctorat pour un CDD de 12 à 15 mois.

Le poste est basé à l’université Clermont-Auvergne (Faculté de Médecine), dans l’unité de nutrition humaine, équipe alimentation santé musculaire et sarcopénie.

La personne sera impliquée dans un programme financé par la région Auvergne Rhône Alpes, visant à étudier les effets d’une approche pharmaco-nutritionnelle envers la fonte musculaire liée à l’induction d’une arthrite chez le rongeur. Les travaux concerneront l’étude du métabolisme énergétique, de l’inflammation, la physiologie musculaire. Le (la) cherch.eur (.euse) aura la charge d’effectuer des analyses d’expression de protéines, de gènes et de coupes histologiques et d’activité enzymatiques issus de prélèvements animaux, le traitement statistique des résultats. Des compétences dans les techniques de Western-Blot, une excellente rigueur scientifique afin de garantir la traçabilité des données sont indispensables. Des compétences en histologie et en PCR seront un atout important.

L’offre est à pouvoir dès que possible (envisager septembre, le temps de l’instruction du dossier).

Contacts responsables :
Frederic Capel
Frederic.capel@inrae.fr

Anne Tournadre
atournadre@chu-clermontferrand.fr


Scientist Position – Muscular disorders

Role & responsabilities:
• Design R&D programs and define adequate resources to complete the program successfully
• Propose new internal R&D programs
• Independently execute experiments and rigorously analyze and interpret the results
• Report results to CYTOO’s partners, write activity reports
• Drive at least one technician

If you are interested in this position, please send your resume and cover letter to eventre@cytoo.com.

Pour plus de détail cliquez ici.


Recrutement d’un.e Ingénieur.e en Protéomique

Poste à pourvoir à partir de septembre 2020

Nous souhaitons recruter, pour un contrat d’un an, un.e ingénieur.e spécialisé en protéomique avec une bonne connaissance de la biochimie des protéines, de la spectrométrie de masse, des systèmes chromatographiques et des principaux outils d’analyse de données de spectrométrie de masse. Des connaissances en bio-informatique seraient un plus. La personne recrutée prendra en charge nos prestations de recherche, en collaboration avec les chercheurs, ainsi que les projets de recherche et développements propres à la plateforme. Il ou elle devra faire preuve de rigueur, être autonome et avoir le sens de l’organisation. Les qualités relationnelles et le sens du service sont également essentielles au regard du caractère collaboratif inhérent au travail de plateforme technologique.

Missions
• Réaliser la préparation des échantillons protéiques, appliquer et adapter les techniques de biochimie
• Mettre en oeuvre les techniques de spectrométrie de masse couplée à la chromatographie liquide à haute performance
• Analyser les données LC-MS/MS
• Rédiger des rapports et des notes techniques
• Interagir avec les utilisateurs de la plateforme et les accompagner en amont et en aval de l’analyse protéomique
• Participer aux opérations de maintenance des équipements
• S’impliquer dans la démarche qualité

Merci d’envoyer un CV et une lettre de motivation avec des références à Solenne Chardonnet (solenne.chardonnet@sorbonne-universite.fr) et Gisèle Bonne (gisele.bonne@sorbonne-universite.fr)

Pour plus de détail cliquez ici.


Postdoctoral Position in neurodegenerative diseases at Ecole Normale Supérieure

The Triller lab together with the Strick lab at the Institute of Biology at Ecole Normale Supérieure (IBENS) is seeking a postdoctoral scientist for a joint project focused on studying “New pathological mechanisms involved in Alzheimer’s disease: toward innovative therapeutic approaches.” Research in Antoine Triller’s lab is focused on membrane molecules which regulate the function of synapses by using cell and molecular biology together with single molecule imaging (sptPALM). Research in Terence Strick’s lab uses physical methods involving magnetic tweezers together with single-molecule imaging (NanoCOSM) to follow molecular interactions in real-time at the single molecule level.

Requirements:
• PhD or MD/PhD with a background in cell biology and neuroscience.
• Significant technical expertise in imaging and basic biophysics.
• Experience studying neurodegenerative disease is welcome but not required.
• Evidence of productivity from publications in peer-reviewed journals originating from Ph.D. or postdoctoral work.
• Excellent verbal and written communication skills in English
• Excellent organizational skills, self-motivation, and creativity.

Please send a cover letter explaining your relevant work experience and interests, a CV, and the contact information of three references to Dr Triller antoine.triller@ens.psl.eu
and Prof. Strick terence.strick@ens.psl.eu

For more details click here.


PhD position in DNA repair

Workplace: CEA 92265 Fontenay aux roses, Genome Instability and Nuclear Organisation Laboratory, IRCM, F. Jacob institute, UMR
Supervision : Dr Karine Dubrana
Type of contract: PhD student contract (CEA Funded)
Contract period: 36 months
Start date of the thesis: From October 1rst 2020

Objective of research: explore the mechanism insuring chromosome integrity at DNA double strand break sites

Application: The candidate must hold a an engineering or Master degree in biology. A background in molecular genetics and/or microscopy will be a plus.

Please send a single PDF with the following documents to Dr Karine Dubrana (karine.dubrana@cea.fr):
1. A detailed CV a,d motivation letter explaining why you want to join the lab, what you know and what you want to learn.
2. A short summary of your MSc research
3. At least two academic references (people who may be contacted)
4. Copies of university transcripts

For more details click here.