Annonces professionnelles

Postdoctoral position available

 

Description: A postdoctoral position is available in the team of Bertrand Fontaine & Laure Strochlic for a research project supported by AFM-telethon aiming at exploring the role of new master regulators at the neuromuscular junction (NMJ) in physiological and pathological conditions using mouse models and a wide-range of cell biology and imaging techniques.
The team has a long standing expertise in the neuromuscular field spanning from fundamental to translational research programs focusing on the Vertebrate NMJ. We use various cellular (primary and immortalized cells) and animal (mouse) models to explore the molecular mechanisms underlying NMJ formation and maintenance with the ultimate goal of developing new therapeutic strategies for NMJ-related diseases.

Qualifications: Candidates should have a PhD or equivalent and an excellent track record and expertise in the (Neuro) myology field, as well as expertise with mouse models, cell biology and imaging techniques. A previous background and experience with the NMJ is a plus.

Application Details: Candidates should send their application with full supporting documentation (CV, publication list, short description of previous research project(s), and names and adresses of 2 referees) to Laure Strochlic laure.strochlic@inserm.fr

Date: The position is available from February 2021

Fore more details, click here.


Postdoctoral Position in Mitochondrial Ca2+ Regulation & Cardiac Ischemia-Reperfusion Injury

 

Workplace: One postdoctoral research fellow position is open in the IRIS team (Ischemia-Reperfusion Injury Syndromes) from the CarMeN lab (Cardiovascular, Metabolism & Nutrition) in Lyon, France. The goal of the IRIS team, gathering both scientists and clinicians, is to unravel the physiopathology of the IR syndromes in the heart, brain and kidney, by combining fundamental, translational and clinical approaches. One of the main axes focuses on the molecular mechanisms through Ca2+, mitochondria and metabolism.

Project: Myocardial infarction remains a frequent and disabling disease with still no therapeutic strategy to mitigate the risk of developing heart failure. The mitochondrial Ca2+ uniporter (mtCU) represents the key structure which controls Ca2+ entry inside mitochondria and therefore a relevant target upstream of the mitochondrial Ca2+ overload to modulate not only cell death but also mitochondrial bioenergetics and Ca2+ homeostasis. Following the recent discovery of the mtCU components and of its regulation, this project aims at determining the molecular mechanisms controlling the mtCU composition and localization during cardiac ischemia-reperfusion. Our hypothesis will be tested through three original tasks from molecular to whole animal scale, up to the translational level in human cardiomyocytes. The project and the position are fully funded by the French ANR.

Please send the following documents to Dr. Mélanie PAILLARD melanie.gomez@inserm.fr
1. A detailed CV and a motivation letter.
2. A short summary of your Ph.D. thesis, and if applicable, of previous post-doc.
3. The name and contact information for two academic references.

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Postdoctoral position available

Centre de Recherche en Myologie, Sorbonne Université-Inserm U974, Institut de Myologie
Groupe Hospitalier Pitié‐Salpêtrière, Paris, France.

Description: A postdoctoral position is available in the team of Bertrand Fontaine & Laure Strochlic for a research project supported by AFM-telethon aiming at exploring the role of new master regulators at the neuromuscular junction (NMJ) in physiological and pathological conditions using mouse models and a wide-range of cell biology and imaging techniques. The team has a long standing expertise in the neuromuscular field spanning from fundamental to translational research programs focusing on the Vertebrate NMJ. We use various cellular (primary and immortalized cells) and animal (mouse) models to explore the molecular mechanisms underlying NMJ formation and maintenance with the ultimate goal of developing new therapeutic strategies for NMJ-related diseases.

Qualifications: Candidates should have a PhD or equivalent and an excellent track record and expertise in the (Neuro) myology field, as well as expertise with mouse models, cell biology and imaging techniques. A previous background and experience with the NMJ is a plus.

Date: The position is available from February 2021

Application Details: Candidates should send their application with full supporting documentation (CV, publication list, short description of previous research project(s), and names and adresses of 2 referees) to: laure.strochlic@inserm.fr.

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ANR-funded Postdoctoral position available at Marseille Medical Genetics, Marseille, France

Epigenetics, Chromatin and Disease modelling team

Our team is interested in modeling skeletal muscle differentiation and diseases using pluripotent stem cells. In collaboration with the Lasers Plasma and Photonic Processes laboratory (LP3, UMR 7341 CNRS-Aix Marseille University- AMU), we are developing an interdisciplinary project aimed at applying high resolution laser-assisted bioprinting and surface structuration for engineering skeletal muscle tissue using human induced pluripotent stem cells.

The position is funded by ANR for 18 months. Further extension is possible. We are seeking for a highly motivated researcher with experience in cell biology, cell culture and stem cells and a strong interest in stem cell biology. The applicant will work in close collaboration with physicists. Ability to work independently but also with a good team spirit in a multi thematic environment is necessary. Candidates with competence in stem cell biology or biomaterials are welcome. Experience in cell culture in needed.

Deadline for application is April 1rst 2021.

To apply, please send your curriculum vitae, motivation letter and the names/contact information of 2/3 referees to: frederique.magdinier@univ-amu.fr.

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CALL for a NEW RESEARCH GROUP LEADER
CLERMONT-FERRAND, FRANCE

The GReD Institute located at Clermont-Ferrand, France opens a position of Independent Group Leader in human mobility related fields including muscle development, metabolism and pathologies (see annex for details).

Candidates must have completed at least 3 years of postdoctoral training in a country different from that of their PhD graduation. Candidates currently holding a postdoctoral position in Clermont-Ferrand are not eligible. Applications should include a cv, a short description of achievements and a record of self-financing, accompanied by the proposed research program (5 pages maximum) and contact details for 3 professional references. Early career or established scientists are welcome to apply. The GReD Institute promotes diversity and inclusion in science and underrepresented minorities in research are encouraged to apply.

The final deadline for applications is noon, January 31st 2021. Shortlisted candidates will be invited for interview with an international scientific committee.

Please send your application as a single PDF file of approximately 6/10 pages named LASTNAME_Lab XX_2021.pdf to: direction.gred@uca.fr.

Fore more details, click here.


Poste Technicien supérieur – Institut Pasteur
2 ans à partir de décembre 2020

Nous recherchons un(e) technicien(ne)/Ingénieur(e) ayant une expertise dans plusieurs de ces domaines suivants : histologie, biologie cellulaire, culture cellulaire, expérimentation animale (souris), expertise de travail en P2+/P3 est un plus, compréhension de l’anglais.

Veuillez envoyer un seul PDF avec lettre de motivation (1 page maximum) + curriculum vitae et coordonnées de vos références au Dr. Barbara Gayraud-Morel à l’adresse mail : bgayraud@pasteur.fr.

Pour plus d’informations, cliquez ici.


Postdoctoral position in muscle Stem Cell biology and neuromuscular translational research

Post-doctoral positions are available in the team directed by Pr Frédéric Relaix at Mondor Institute of Biomedical Research (IMRB) in Paris-Est Creteil, France.

A PhD with a strong background in molecular biology, and/or mouse molecular genetics, stem cell biology, skeletal muscle (both fundamental biology and preclinical research), cell culture/biology and/or histology is strongly advised. Solid computer skills (word, powerpoint, graphs, statistics, image analysis) are required. In addition, the candidate will help to train and supervise Master and PhD students.

Selected candidates should be enthusiastic and highly motivated to work in a dynamic, multicultural and well-funded scientific environment. Scientific English, good writing and oral presentation skills, and relevant publication record are required. Foreign candidates (notably EC members) are encouraged to apply.

Applications, including motivated scientific interests, suitability and career plans, a detailed CV, including a summary of candidate’s research experience, a list of publications and communications and the name of two referees should be sent to Pr Frédéric Relaix (julien.courchet@univ-lyon1.fr)and Relaix Lab management (relaixlab@gmail.com).

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Postdoctoral position in Neurobiology
Lyon, France

A postdoctoral position is available in the laboratory of Julien Courchet at the NeuroMyoGene Institute within the University of Lyon, France.

Applicants should have a PhD degree or equivalent with a strong background and practical experience in neurobiology, confocal microscopy and/or real-time imaging. Previous experience working with rodent models is required. Training in techniques relevant to cell signaling, metabolic regulation and optogenetics would be an asset. We are looking for a highly motivated candidate with a strong attitude towards independent work and good interpersonal and communication skills.
Excellent written and spoken English skills are essential. Ability to speak French in not mandatory.
Candidates should hold a PhD in Neuroscience. Experience in cellular electrophysiology is mandatory and some background in cell imaging, in vivo electrophysiology or optogenetics would be a plus. The candidate should be highly motivated and organized, have good communication skills and should speak and write English fluently.

Interested candidates should contact Dr Julien Courchet (julien.courchet@univ-lyon1.fr) with their CV, a summary of their previous research (< 1 page), a brief statement of their research interests and career goals, as well as the contact information for at least 3 references.

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A two year postdoctoral position is available immediately at the Institut de Génomique Fonctionnelle (IGF, Montpellier)

Microglia in the wiring of Inhibitory circuits during sensory cortex critical periods (ANR MicroSenso)

the MicroSenso project aims at studying the mechanisms by which microglial cells influence the wiring of inhibitory circuits during developmental critical periods of sensory cortices. The project will combine different functional approaches (ex vivo slice and in vivo electrophysiology, calcium imaging and optogenetics) to analyze different mouse models (microglia depletion, maternal immune activation, microglia and interneurons conditional KI and KO mice). The project funded by ANR will be performed in the team “Cerebrovascular and Glia Research” (Co-PIs E Audinat & N Marchi) of the IGF in Montpellier and in collaboration with the teams of S Garel (ENS, Paris) and N Rouach (Collège de France, Paris).

Candidates should hold a PhD in Neuroscience. Experience in cellular electrophysiology is mandatory and some background in cell imaging, in vivo electrophysiology or optogenetics would be a plus. The candidate should be highly motivated and organized, have good communication skills and should speak and write English fluently.

Send your CV and a motivation letter mentioning two references to etienne.audinat@igf.cnrs.fr.

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Funded PhD project at IGBMC – Strasbourg – France

Project :
The PhD student will use next generation sequencing strategies, exome and genome sequencing of patients DNA, and RNAseq/transcriptome from patient muscles, and process these big datasets through bioinformatics pipelines to identify mutated genes in patients with myopathies. The functional impact of mutations will be confirmed by in vitro assays with recombinant proteins and transfected and differentiated muscle cells followed by confocal and video microscopies. The importance of these new myopathy genes for muscle function will be evaluated in vivo in an animal model (zebrafish or mice depending on the gene conservation) with CRISPR/Cas9 genome editing, RNA interference and adeno-associated virus. Animals will be phenotyped with simple motor tests, histology, electron microscopy and confocal imaging. This will also provide faithful laboratory models in which therapies may be later tested.
The success of this project will lead to a better diagnosis and patient care, and the identified genes will increase our understanding of the pathomechanisms and represent novel therapeutic targets.

Application:
Please send your CV, letters of recommendation and Master results to J Laporte (jocelyn@igbmc.fr) and J Bohm (johann@igbmc.fr)

Fore more details, click here.


Post-doctoral position at the Institute of Genetics and Molecular and Cellular Biology

(Illkirch, France) in the team of Daniel Metzger

The project aims at understanding the molecular mechanisms underpinning the tissue specificity and the crosstalk between steroid hormone receptors through integrative analyses. Our team has recently developed projects based on genomewide characterization of transcription factor cistromes and transcriptomes in various tissues of genetically modified mice, thereby providing the unique opportunity to decipher the in vivo mode of action of nuclear receptors. The fellow’s tasks will be to identify tissuespecific receptor partners and characterize the associated epigenetic marks using cuttingedge technics like Atac-seq, Hi-C and Rapid Immunoprecipitation Mass Spectrometry (RIME). Genome-wide data obtained in various tissues will be strengthened in in vitro models to delineate these complex molecular mechanisms.

Candidates should send a curriculum vitae with a publication list, a short summary of research achievements and mastered techniques, as well as contact information of at least two references to metzger@igbmc.fr.

For more details click here.


Chercheur CDD biologie du muscle (sarcopénie et pathologie inflammatoire)

Offre pour un (.e) jeune cherch.eur (.euse) titulaire d’un doctorat pour un CDD de 12 à 15 mois.

Le poste est basé à l’université Clermont-Auvergne (Faculté de Médecine), dans l’unité de nutrition humaine, équipe alimentation santé musculaire et sarcopénie.

La personne sera impliquée dans un programme financé par la région Auvergne Rhône Alpes, visant à étudier les effets d’une approche pharmaco-nutritionnelle envers la fonte musculaire liée à l’induction d’une arthrite chez le rongeur. Les travaux concerneront l’étude du métabolisme énergétique, de l’inflammation, la physiologie musculaire. Le (la) cherch.eur (.euse) aura la charge d’effectuer des analyses d’expression de protéines, de gènes et de coupes histologiques et d’activité enzymatiques issus de prélèvements animaux, le traitement statistique des résultats. Des compétences dans les techniques de Western-Blot, une excellente rigueur scientifique afin de garantir la traçabilité des données sont indispensables. Des compétences en histologie et en PCR seront un atout important.

L’offre est à pouvoir dès que possible (envisager septembre, le temps de l’instruction du dossier).

Contacts responsables :
Frederic Capel
Frederic.capel@inrae.fr

Anne Tournadre
atournadre@chu-clermontferrand.fr


Scientist Position – Muscular disorders

Role & responsabilities:
• Design R&D programs and define adequate resources to complete the program successfully
• Propose new internal R&D programs
• Independently execute experiments and rigorously analyze and interpret the results
• Report results to CYTOO’s partners, write activity reports
• Drive at least one technician

If you are interested in this position, please send your resume and cover letter to eventre@cytoo.com.

Pour plus de détail cliquez ici.


Postdoctoral Position in neurodegenerative diseases at Ecole Normale Supérieure

The Triller lab together with the Strick lab at the Institute of Biology at Ecole Normale Supérieure (IBENS) is seeking a postdoctoral scientist for a joint project focused on studying “New pathological mechanisms involved in Alzheimer’s disease: toward innovative therapeutic approaches.” Research in Antoine Triller’s lab is focused on membrane molecules which regulate the function of synapses by using cell and molecular biology together with single molecule imaging (sptPALM). Research in Terence Strick’s lab uses physical methods involving magnetic tweezers together with single-molecule imaging (NanoCOSM) to follow molecular interactions in real-time at the single molecule level.

Requirements:
• PhD or MD/PhD with a background in cell biology and neuroscience.
• Significant technical expertise in imaging and basic biophysics.
• Experience studying neurodegenerative disease is welcome but not required.
• Evidence of productivity from publications in peer-reviewed journals originating from Ph.D. or postdoctoral work.
• Excellent verbal and written communication skills in English
• Excellent organizational skills, self-motivation, and creativity.

Please send a cover letter explaining your relevant work experience and interests, a CV, and the contact information of three references to Dr Triller antoine.triller@ens.psl.eu
and Prof. Strick terence.strick@ens.psl.eu

For more details click here.